Preimplantation Genetic Testing (PGT-M)

Through preimplantation genetic testing-M (PGT-M for monogenic), previously known as preimplantation genetic diagnosis (PGD), at our fertility center, the likelihood that a known genetic disorder will be passed on to a child is reduced. It uses in vitro fertilization (IVF) to create embryos which are subsequently screened for specific genetic mutations. At Fertility Specialists of Texas, our doctors and staff are experienced in handling complex and difficult cases involving PGT-M.

About PGT-M

When a couple has a genetic defect in their family history, they may seek PGT-M in order to increase the chance of having a healthy baby. After eggs are recovered from the ovary as part of the IVF process, they are fertilized to form embryos. A biopsy is then performed to remove 5-7 cells from the embryos. The gene that carries the disease is analyzed for the presence of the disease-causing mutation. Those embryos that show normal biopsy results can then be selected for transfer into the uterus during a subsequent frozen embryo transfer cycle.

Through state-of-the-art PGT-M techniques, our physicians and staff are able to screen for a wide variety of diseases. Cystic fibrosis, sickle cell anemia, Huntington’s disease, and other genetic conditions can have a significant impact on a child’s quality of life. When a genetic disease is part of a family’s history, PGT-M offers new hope.

Limitations

It should be noted that there are limitations associated with PGT-M testing. Not all genetic diseases can be screened for and the absence of a genetic condition cannot be determined with 100% certainty. During your consultation, our physicians and staff will help you fully understand all aspects of PGT-M treatment.

Examples of specific genetic diseases PGT-M has been utilized to prevent:

  • Achondroplasia
  • Adenosine Deaminase Deficiency
  • Alpha-1-Antitrypsin Deficiency
  • Alzheimer’s Disease (AAP gene)
  • Betathalasemia
  • Cystic Fibrosis
  • Epidermolysis Bullosa
  • Fanconi Anemia
  • Gaucher’s Disease
  • Hemophilia A and B
  • Huntington’s Disease
  • Muscular Dystrophy (Duchenne and Becker)
  • Myotonic Dystrophy
  • Neurofibromatosis Type 1
  • OTC Deficiency
  • P53 cancers
  • Phenylketonuria
  • Retinitis Pigmentosa
  • Sickle Cell Disease
  • Spinal Muscular Atrophy
  • Tay Sachs Disease
  • Any genetically abnormal embryos (Trisomy 21, 13)

We are able to offer PGT-M for any genetic disorder for which the sequence DNA information is known; the list increases as new genes are identified.

For PGD, we use: CooperGenomics NJ:
3 Regent Street, Suite 301
Livingston, NJ 07039
Phone: 1-877-282-3112


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